发明名称 |
COMPOSITIONS AND METHODS FOR THE DELIVERY OF NITRIC OXIDE |
摘要 |
H-NOX proteins are mutated to exhibit improved or optimal kinetic and thermodynamic properties for blood gas NO delivery. The engineered H-NOX proteins comprise mutations that impart altered NO or O2 ligand-binding relative to the corresponding wild-type H-NOX domain, and are operative as physiologically compatible mammalian blood NO gas carriers. The invention also provides pharmaceutical compositions, kits, and methods that use wild-type or mutant H-NOX proteins for the treatment of any condition for which delivery of NO is beneficial. |
申请公布号 |
CA2653101(C) |
申请公布日期 |
2016.12.13 |
申请号 |
CA20072653101 |
申请日期 |
2007.05.21 |
申请人 |
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA |
发明人 |
CARY, STEPHEN P. L.;BOON, ELIZABETH M.;WINGER, JONATHAN A.;MARLETTA, MICHAEL A. |
分类号 |
C07K14/47;A61K9/127;A61K9/14;A61K33/00;A61K38/16;A61K38/17;A61K38/42;A61P9/00;C07K14/195;C07K14/435;C12N15/12;C12N15/31;C12P21/02 |
主分类号 |
C07K14/47 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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