发明名称 |
A method of controlling the empimeric distribution in the preparation of 16,17-acetals or ketals of pregnane derivatives. |
摘要 |
<p>A method of controlling the epimeric distribution in the preparation of 16,17-acetals of pregnane derivatives characterized in reaction of a corresponding 16,17-acetonide with an aldehyde or ketone in a) hydrocarbon solvent wherein the solubility of the pregnane derivative is less than 1 mg/l or in a halogenated hydrocarbon solvent together with a hydrohalogen acid or an organic sulphonic acid as catalyst and in the presence of small grains of an inert material in the reaction medium or b) a halogenated hydrocarbon solvent together with a hydrohalogen acid an organic sulphonic acid as catalyst and in the presence of an epimeric distribution modifier.</p> |
申请公布号 |
EP0262108(A1) |
申请公布日期 |
1988.03.30 |
申请号 |
EP19870850282 |
申请日期 |
1987.09.18 |
申请人 |
ASTRA PHARMACEUTICAL PRODUCTION AB |
发明人 |
JAKUPOVIC, EDIB;SOURANDER, ROY TORVALD;STENHEDE, JAN URBAN;SVENSSON, ROLF PETER |
分类号 |
C07J71/00;(IPC1-7):C07J71/00 |
主分类号 |
C07J71/00 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|