PROCESS FOR PREPARATION OF THE THIAZOLIDINYL ALKYLENE PIPERAZINE DERIVATIVES

摘要

The novel compds. having formula (I) or its pharmaceutically acceptable non-toxical acid addn. salts are prepd. by reacting thiazolidindion with piperazine in a inert rxn. media in the presence of base or not at 50-200 deg.C for sufficient time. In the formula, R1=lower alkyl or H, n=2-5 integer, Z=(II) [R2=H, halogen, lower alkyl, lower alkoxy or trifluoromethyl; howerer when n=3, 4 or 5, z=(III) [R3=H or CN . (I) have selective CNS (central nervous system) activity.