| 发明名称 |
Bordetella pertussis toxin with altered toxicity. |
| 摘要 |
<p>Immunologically active polypeptides with no or reduced toxicity useful for the preparation of an antipertussis vaccine. Method for the preparation of said polypeptides which comprises, cultivating a microorganismtransformed with a hybrid plasmid including the gene/s which codes for at least one of said polypeptides in a suitable medium and recovering the desired polypeptide from the cells or from the culture medium.</p> |
| 申请公布号 |
EP0322533(A1) |
申请公布日期 |
1989.07.05 |
| 申请号 |
EP19880117742 |
申请日期 |
1988.10.25 |
| 申请人 |
SCLAVO S.P.A. |
发明人 |
PIZZA, MARIAGRAZIA;RAPPUOLI, RINO;BARTOLONI, ANTONELLA |
| 分类号 |
A61K39/00;A61K39/10;A61P31/04;C07H21/04;C07K14/00;C07K14/195;C07K14/235;C07K14/41;C12N1/20;C12N1/21;C12N15/09;C12P21/00;C12P21/02;C12R1/19 |
主分类号 |
A61K39/00 |
| 代理机构 |
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代理人 |
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| 主权项 |
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| 地址 |
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