| 摘要 |
The subject of the invention is peptide derivatives corresponding to formula X1- X2- Gly - Asp-X3- X4 (I) in which: X1 represents a hydrogen atom, a N-protecting group, an amino acid residue or a N-protected amino acid residue, X2 represents a residue of L-Arg or D-Arg, L-Orn or D-Orn, N-aminocarbonyl -L-Orn or N-aminocarbonyl-D-Orn, or L-Lys, or D-Lys, X3 represents a residue of L-Trp, D-Trp, L-Leu, D-Leu, L-Ile, D-Ile, L-Phe, D-Phe or a chain of 2 or 3 of these residues, and X4 represents a -OH group, -NH2 group, -OR1 group in which R1 represents an alkyl radical of C1 to C4, a NHR2 group in which R2 represents an alkyl radical of C1 to C4, or an amino acid residue. These derivatives are useful in therapy on account of their platelet aggregation inhibiting activity.
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