Vaccine composition

摘要

An intraorally administrable vaccine composition useful to be a preventive or therapeutic agent for infectious diseases, and effectively induces a systemic immune response or a mucosal immune response is provided. A vaccine composition for administration to the oral cavity of a human or an animal, the vaccine composition containing at least one antigen derived from an infectious disease, and at least one selected from the group consisting of a toll-like receptor 4 (TLR4) agonist, a toll-like receptor 2/6 (TLR2/6) agonist, and cyclic dinucleotide, or a derivative or salt thereof.

主权项

1. A vaccine composition for administration to the oral cavity mucosa of a human or an animal, the vaccine composition comprising:
at least one antigen derived from an infectious disease, and an adjuvant-effective amount of lipopolysaccharide or salt thereof, wherein the lipopolysaccharide or salt thereof is derived from Pantoea, wherein the vaccine composition induces a mucosal immune response and a systemic immune response, the mucosal immune response being antigen-specific IgA antibody production, and the systemic immune response being antigen-specific IgG antibody production and antigen-specific cell-mediated immune production.