| 发明名称 |
HETEROATOMIC OLIGONUCLEOSIDE LINKAGES |
| 摘要 |
Oligonucleotide-mimicking macromolecules that have improved nuclease resistance are provided. Replacement of the normal phosphorodiester inter-sugar linkages found in natural oligonucleotides with three or four atom linking groups provide unique oligonucleotide-mimicking macromolecules that are useful in regulating RNA expression and in therapeutics. Methods of synthesis and use also are disclosed. |
| 申请公布号 |
WO9400467(A1) |
申请公布日期 |
1994.01.06 |
| 申请号 |
WO1993US04770 |
申请日期 |
1993.05.19 |
| 申请人 |
ISIS PHARMACEUTICALS, INC. |
发明人 |
COOK, PHILLIP, DAN;SANGHVI, YOGESH, SHANTILAL |
| 分类号 |
C12N15/00;A01N43/08;A61K31/70;A61K31/7088;A61P31/12;A61P35/00;C07D405/04;C07D405/14;C07F7/18;C07H19/04;C07H19/06;C07H19/10;C07H19/16;C07H21/00;C07H21/04;C12Q1/68;(IPC1-7):C07H17/00;H01M12/00;A01N43/04;C07H15/12;C12Q01/68 |
主分类号 |
C12N15/00 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
|
| 地址 |
|
