DERIVATED DTPA COMPLEXES, PHARMACEUTICALS CONTAINING THESE COMPOUNDS, THEIR USE AS NMR- AND RADIOGRAPHIC CONTRASTING AGENTS AND PROCESS FOR PRODUCING THE SAME

摘要

Complex compounds and their salts consist of at least one metal ion and a complexing agent having general formula (I), in which Z<1> and Z<2> represent independently from each other a hydrogen atom, the residue -(CH2)m-(C6H4)q-(O)k-(CH2)n-(C6H4)l-(O)r-R, or the residue -(CH2)m-(C6H10)q-(O)k-(CH2)n-(C6H10)l-(O)r-R, in which m and n are the numbers 0-5, q, k, l and r are the numbers 0 or 1 and s is the number 1 or 2; R stands for a hydrogen atom, an if required OR<1>- substituted, straight-chain or branched-chain C1-C6-alkyl residue or a CH2-COOR<1> group, in which R<1> stands for a hydrogen atom, a C1-C6-alkyl residue or a benzyl group, with the proviso that one of the substituents Z<1> or Z<2> stands for a hydrogen atom and the other does not, and that a direct oxygen-oxygen bond is not allowed. Also disclosed is their use for producing radiotherapy agents and NMR and radiographic diagnosing agents, in particular for contrasting the hepatobiliary system. A process for producing these compounds and agents is further disclosed.