| 摘要 |
Retinoid like activity is exhibited by compounds of the formula <IMAGE> where R1-R3 independently are hydrogen, lower alkyl, cycloalkyl or lower alkenyl, A and B independently are hydrogen, lower alkyl, cycloalkyl, lower alkenyl, SR4 or OR4 where R4 is lower alkyl, cycloalkyl or lower alkenyl; Y is selected from a group consisting of pyridazinyl, pyrimidinyl, pyrazinyl, thiazolyl or oxazolyl; E is lower alkenyl, lower alkynyl, lower cycloalkyl, lower branched chain alkyl, or is characterized by the formula (CH2)n where n is 0-5, and Z is H, OH, OR5, OCOR5, -COOH or a pharmaceutically acceptable salt, ester or amide thereof, -CH2OH, CH2OR6, CH2OCOR6, or -CHO, CH(OR7)2, CHOR8O, or COR9, CR9(OR7)2, CR9OR8O where R5 is lower alkyl, phenyl or lower alkylphenyl, R6 is lower alkyl, phenyl or lower alkylphenyl, R7 is lower alkyl, R8 is a divalent alkyl radical of 2-5 carbons, and R9 is an alkyl, cycloalkyl or alkenyl group containing 1 to 5 carbons.
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