PROCESS FOR PRODUCING OLIGONUCLEOTIDES, AND CORRESPONDING INTERMEDIATE COMPOUNDS

摘要

FIELD: microbiology. SUBSTANCE: process for producing numerous oligonucleotides comprises formation of first nucleotide on first cleavable bond attached to solid carrier; attachment of cleavable linker fragment to first oligonucleotide; formation of second nucleotide on cleavable linker fragment and cleavage of first cleavable bond and cleavable linker fragment to form numerous oligonucleotides where cleavable linker fragment of formula (I):wherein A, Aand E are as defined in the specification as well as new compounds which are used in carrying into effect the process. EFFECT: more efficient production process.