| 摘要 |
Described herein are compounds selective for 5-HT1D-like receptors, which have the general formula: l and aryl substituted with 1, 2 or 3 substituents independently selected from loweralkyl, loweralkoxy, loweralkylcarbonyl, loweralkyl-S-, loweralkyl-S(O)-, loweralkyl-SO2-, S=C=N-, O=C=N-, halo, loweralkoxycarbonyl, nitro, amino, loweralkyl-NH-, (loweralkyl)2-N-, loweralkyl-SO2-loweralkyl-; A is a double or triple bond; R2 is selected from a group of Formula II, III, IV and V: <IMAGE> II <IMAGE> III <IMAGE> IV <IMAGE> V R3 is selected from H and loweralkyl; R4 is selected from H and loweralkyl; One of R5 and R6 is H and the other is independently selected from H, loweralkoxy, loweralkyl and hydroxy; and R7 and R8 are independently selected from H and loweralkyl or R7 and R8, together with the nitrogen atom to which they are attached, form an optionally substituted 3- to 6-membered ring; or a salt, solvate or hydrate thereof. Also described is the use of these compounds as pharmaceuticals to treat indications where stimulation of the 5-HT1D-like receptor is implicated, such as migraine.
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