发明名称 |
Monoclonal antibody to alpha2-macroglobulin and its use for detecting glucan |
摘要 |
The present invention is directed to monoclonal antibodies which specifically bind to a Limulus alpha 2-macroglobulin. Preferred monoclonal antibodies inhibit the enzymatic activation of a Limulus amebocyte lysate to form a gel or to cleave a chromogenic substrate in the presence of an endotoxin but not in the presence of a glucan. The monoclonal antibodies can be used, inter alia, to purify a Limulus alpha 2-macroglobulin, and the preferred antibodies can be used in a method for specifically detecting a glucan in a test sample using an amebocyte lysate. |
申请公布号 |
AU1094999(A) |
申请公布日期 |
1999.05.03 |
申请号 |
AU19990010949 |
申请日期 |
1998.10.16 |
申请人 |
BIOWHITAKER TECHNOLOGIES |
发明人 |
CHRISTOPHER J. HERBSTRITT;MICHAEL G. PEPE |
分类号 |
G01N33/577;C07K1/22;C07K16/18;C07K16/38;C07K17/00;C12N5/10;C12N5/20;C12N15/02;G01N33/53;G01N33/579 |
主分类号 |
G01N33/577 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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