| 摘要 |
Disclosed herein are bicyclo[3.2.1]octyl amide derivatives of formula I wherein L is -NHCO- or -CONH- and R1 and R2 are both heteroaryl independently substituted with at least one substituent selected from alkyl and halogen and pharmaceutically acceptable salts thereof. Examples of the compounds of formula I include N,N-(bicyclo[3.2.1]octane-1,5-diyl)bis(6-methylpicolinamide) and 2-methyl-pyrimidine-4-carboxylic acid{ (1S,5R)-5-[(6-methyl-pyridine-2-carbonyl)-amino]-bicyclo[3.2.1]oct-1-yl} -amide. Also disclosed is the use of these compounds for treating central nervous system diseases or disorders such as anxiety disorder, panic anxiety, obsessive compulsive disorder, social phobia, performance anxiety, post-traumatic stress disorder, acute stress reaction, an adjustment disorder, a hypochondriacal disorder, separation anxiety disorder, agoraphobia, a specific phobia, anxiety disorder due to general medical condition, substance induced anxiety disorder, alcohol withdrawal-induced anxiety and depression. |
