发明名称 |
Process for preparation of pharmaceutical composition with dextro-and laevo-rotatory isomers of sotalol |
摘要 |
<p>Antiarrhythmic composition with controlled beta -adrenergic blockade comprises a combination of dextro- and laevo-rotatory isomers of sotalol or their salts in a ratio of 1.5:1-3.5:1. An independent claim is included for an oral or parenteral composition for treating cardiac ailments which comprises a combination of dextro- and laevo-isomers of sotalol. ACTIVITY : Antiarrhythmic; cardiant. In a test using Guinea pigs (Dunken Hartley) to demonstrate antiarrhythmic activity of different ratios of sotalol, ouabain was used to produce ventricular tachycardia. Sotalol (2:1 ratio (d:l)) resulted in complete protection against ventricular tachycardia at a dosage of 2.5 mg/kg. MECHANISM OF ACTION : beta -adrenergic antagonist.</p> |
申请公布号 |
IN188162(B) |
申请公布日期 |
2002.08.31 |
申请号 |
IN1999KO08919 |
申请日期 |
1999.02.05 |
申请人 |
TORRENT PHARMACEUTICALS LTD. |
发明人 |
SANKARANARAYNAN ALANGUDI |
分类号 |
A61P9/00;A61K9/00;A61K31/18;A61P9/06;A61P25/02;C07C311/08;(IPC1-7):A61K31/63 |
主分类号 |
A61P9/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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