发明名称 |
ANTI-EGFR EINKETTIGE FVS UND ANTI-EGFR ANTIKOERPER |
摘要 |
PCT No. PCT/EP95/00978 Sec. 371 Date Nov. 17, 1995 Sec. 102(e) Date Nov. 17, 1995 PCT Filed Mar. 16, 1995 PCT Pub. No. WO95/25167 PCT Pub. Date Sep. 21, 1995This invention relates to new anti-EGFR antibodies and single-chain Fvs (scFvs) thereof which can be obtained from phage-antibody libraries constructed from cells of an immunized mammalian, preferably a mouse. Two of the single-chain Fvs isolated from the phage-antibody libraries were engineered to create partially humanized whole antibody molecules. These chimeric anti-EGFR antibodies contain constant regions of human immunoglobulins, and can be used as well as the single-chain Fvs as agents for the diagnosis and therapy of human tumors. |
申请公布号 |
AT232902(T) |
申请公布日期 |
2003.03.15 |
申请号 |
AT19950913134T |
申请日期 |
1995.03.16 |
申请人 |
MERCK PATENT GMBH |
发明人 |
KETTLEBOROUGH, A. CATHRINE;BENDIG, MARY M.;ANSELL, KEITH H.;GUESSOW, DETLEF;ADAN, JAIME;MITJANS, FRANCESC;ROSELL, ELISABET;BLASCO, FRANCESC;PIULATS, JAIME |
分类号 |
G01N33/53;A61K38/00;A61K39/395;A61P35/00;C07K16/00;C07K16/28;C12N15/09;C12N15/13;C12P21/02;C12P21/08;C12R1/19;G01N33/563 |
主分类号 |
G01N33/53 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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