| 摘要 |
<p>3-Fluoro-L-alanine is transformed by asymmetric conversion, via an intermediate L-2-(halo or o-tosyloxy)-3-fluoropropionic acid, to 3-fluoro-D-alanine, or by asymmetric rearrangement of a S-2-(azidocarbonyl or aminocarbonyl)-3-fluoropropionic ester or nitrile to the corresponding 2-isocyanato or ethyl urethane followed by hydrolysis. The 3-fluoro-D-alanine thus obtained is a potent antibacterial agent.</p> |
