DERIVATIVES OF THE TETANUS TOXIN, PROCESS FOR THEIR PREPARATION AND AGENTS CONTAINING THEM

摘要

This invention is directed to a process for the preparation of a modified derivative of the light chain tetanus toxin in which the light chain of tetanus toxin free from denaturing agent is mixed with an aliphatic mono- or di-aldehyde having a chain length of from 1 to 6 carbon atoms, up to an aldehyde concentration of from 0.05 mole to 0.2 mole. The mixture is then allowed to stand for 14 to 28 days at a temperature of from 20 to 37.degree.C, the aldehyde is eliminated and the modified derivative of the light chain is obtained. The invention is also directed to the product prepared according to this process. The products of the invention are useful in the preparation of tetanus vaccines.