发明名称 |
Cyclic dithiodiacetamides and compositions containing them |
摘要 |
The present invention relates to cyclic dithiodiacetamides with action inhibiting the malformation or the destruction of the red blood corpuscles due to a genetic modification of the haemoglobin or to parasites, of formula: <IMAGE> in which X is a direct bond, an atom of oxygen or of sulfur, a methylene group, an ethylene group or an N-R group, where R is an atom of hydrogen or a lower alkyl group, lower (hydroxy)alkyl group, lower alkanoyl group or a phenyl group; to their possible pharmaceutically acceptable salts; to a process for preparing them from a dithiodiacetate or a mercaptoacetate of lower alkyl by transamination and possible oxidation; and to pharmaceutical compositions containing them as active ingredients, useful for the treatment for example of drepanocytosis, or sickle cell anaemia, of malaria and of babebiosis.
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申请公布号 |
US4642306(A) |
申请公布日期 |
1987.02.10 |
申请号 |
US19840611516 |
申请日期 |
1984.05.17 |
申请人 |
SANOFI;INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE |
发明人 |
ROSA, JEAN;CASTAIGNE, JEAN-PAUL;DEMARNE, HENRI;TOZZOLINO, PIERRE |
分类号 |
C07D295/18;A61K31/40;A61K31/535;A61K31/5375;A61P7/00;A61P7/06;A61P33/02;C07D295/185;(IPC1-7):A61K31/535;A61K31/54;C07D265/30;C07D279/12 |
主分类号 |
C07D295/18 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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