| 摘要 |
<p>A compound having the structure (I), where T is of formula (II), where each D?1 and D2¿, independently, is a hydroxyl group or a group which is capable of being hydrolysed to a hydroxyl group in aqueous solution at physiological pH; a group of formula (III), where G is either H, F or an alkyl group containing 1 to about 20 carbon atoms and optional heteroatoms which can be N, S, or O; or a phosphonate group of formula (IV) where J is O-alkyl, N-alkyl, or alkyl, each comprising about 1-20 carbon atoms and, optionally, heteroatoms which can be N, S, or O; T being able to form a complex with the catalytic site of an enzyme, X is a group having at least one amimo acid, Y is (V) or (VI) or (VII) and each R?1, R2, R3, R4, R5, R6, R7, and R8¿ is separately a group which does not interfere significantly (i.e., does not lower the Ki of the compound to less than 10-7M) with site-specific recognition of the compound by the enzyme, and allows a complex to be formed with the enzyme.</p> |
