MONOCLONAL ANTIBODY FOR DIFFERENTIATION OF SQUAMOUS CELL CARCINOMA ANTIGENS AND METHOD OF USE FOR SAME

摘要

The invention is a monoclonal antibody (MAb 174H.64) which selectively recognizes antigens associated with squamous cell carcinoma and stem cell populations of stratified epithelium. In well differentiated squamous cell carcinoma tumors, the antibody preferentially binds with the peripheral proliferative compartment of the tumor. The antigens recognized by MAb 174H.64 include cytoskeletal proteins with molecular weight of approximately 48 to 50kD and 57kD. The method of use of the antibody includes diagnosis of squamous cell carcinoma tumours by immunohistology, non-invasive diagnostic imaging in vivo, treatment of squamous cell carcinoma tumours using MAb conjugates of radionuclide or cytotoxic drugs, all immunopurification of SCC antigens.