发明名称 |
3-FURYL-2-CYANO-2-ACRYLAMIDE DERIVATIVE, PREPARATION METHOD THEREFOR, PHARMACEUTICAL COMPOSITION AND USE THEREOF |
摘要 |
Disclosed are a 3-furyl-2-cyano-2-acrylamide derivative with epidermal growth factor receptor (EGFR) inhibitory activity and pharmaceutical acceptable salt thereof, together with preparation method thereof, pharmaceutical composition comprising the compound, and application of the compound in treating senile dementia (AD). The new compound is shown as formula I, wherein R1 is selected from the group consisting of H, C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl and C3-C6 cycloalkyl; R2 is selected from the group consisting of alkyl, cycloalkyl, alkenyl, alkynyl, aryl, heteroaryl, aralkyl and heteroaralkyl; X is selected from the group consisting of CH2, NH, O and S; m and n are all integers greater than or equal to zero.; |
申请公布号 |
US2016272604(A1) |
申请公布日期 |
2016.09.22 |
申请号 |
US201615170871 |
申请日期 |
2016.06.01 |
申请人 |
JENKEM TECHNOLOGY CO., LTD. (BEIJING) |
发明人 |
FENG ZEWANG;JIA JIANHUAN;LIU YAN;WANG ZHENGUO;ZHAO XUAN |
分类号 |
C07D307/54;C07D405/12 |
主分类号 |
C07D307/54 |
代理机构 |
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代理人 |
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主权项 |
1. A compound of formula I, or a pharmaceutical acceptable salt thereof: wherein R1 is selected from the group consisting of H, C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl and C3-C6 cycloalkyl; R2 is selected from the group consisting of alkyl, cycloalkyl, alkenyl, alkynyl, aryl, heteroaryl, alkaryl, aralkyl and heteroaralkyl; X is (CH2)n or (CH2)nY, wherein n is an integer greater than or equal to zero; Y is NH, O or S; m is an integer greater than or equal to zero. |
地址 |
BEIJING CN |