发明名称 |
PDGF analogs and methods of use |
摘要 |
Proteins having substantially the same biological activity as PDGF are provided. In one aspect, a protein homodimer having two polypeptide chains is disclosed, each of the chains being a mosaic of amino acid sequences substantially identical to portions of the A- and B-chains of PDGF, the protein being chemotactic or mitogenic for fibroblasts. Therapeutic compositions comprising such proteins in combination with a physiologically acceptable carrier or diluent are also provided. Such therapeutic compositions may be used within methods for enhancing the wound-healing process in warm-blooded animals.
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申请公布号 |
US5474982(A) |
申请公布日期 |
1995.12.12 |
申请号 |
US19940273779 |
申请日期 |
1994.07.12 |
申请人 |
ZYMOGENETICS, INC. |
发明人 |
MURRAY, MARK J.;KELLY, JAMES D. |
分类号 |
A61K38/00;C07K14/15;C07K14/49;C12N15/81;(IPC1-7):A61K38/00 |
主分类号 |
A61K38/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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