| 发明名称 |
Mitogen activated c-Fos regulating kinase, FRK |
| 摘要 |
An isolated nitrogen activated c-Fos regulating kinase polypeptide (FRK) having a molecular weight of about 88-kD as determined by reducing SDS-PAGE, having threonine and serine kinase activity, phosphorylating the c-Fos activation domain at amino acid residue Thr 232 and having polynucleotide sequences and a method of detection for FRK are provided herein. Also described are methods for identifying compositions which affect FRK activity, thereby affecting c-Fos activation and subsequent activation of genes associated with AP-1 sites.
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| 申请公布号 |
US5747318(A) |
申请公布日期 |
1998.05.05 |
| 申请号 |
US19960707873 |
申请日期 |
1996.09.09 |
| 申请人 |
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA |
发明人 |
DENG, TILIANG;KARIN, MICHAEL |
| 分类号 |
G01N33/53;A61K31/00;A61K31/70;A61K31/7088;A61K35/76;A61K38/45;A61K39/395;A61K45/00;A61K48/00;A61P1/00;A61P9/00;A61P9/10;A61P9/14;A61P11/00;A61P11/04;A61P13/00;A61P13/12;A61P15/00;A61P29/00;A61P35/00;A61P35/02;A61P37/00;A61P37/04;A61P43/00;C07K16/32;C07K16/40;C07K16/42;C12N1/21;C12N5/10;C12N9/12;C12N15/09;C12P21/08;G01N33/573;(IPC1-7):C12N9/12;A61K38/46;A61K38/47 |
主分类号 |
G01N33/53 |
| 代理机构 |
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