| 摘要 |
PROBLEM TO BE SOLVED: To safely industrially obtain the subject compound important as an intermediate, etc., for a medicine by reducing a Boc derivative of an optically activeα-amino acid by using a readily usable sodium borohydride. SOLUTION: (A) The Boc derivative (Boc is t-Bu-OCO group) of an optically activeα-amino acid of formula I [R is 1-10C alkyl, aralkyl, etc., preferably methyl or isopropyl; (*) represents an asymmetric carbon] is reduced by (B) sodium borohydride to provide (C) an optically active Boc-amino alcohol of formula II. The using amount of the component B is one or more molar times, preferably about 1.5-3 molar times as much as the amount of the component A. The reaction temperature is (-20)-60 deg.C, preferably (-10)-30 deg.C, and the reaction time is about 1-5 hr after finishing the dropping. |
