发明名称 |
Method and identification of downstream mrna ligands to fmrp and their role in fragile x syndrome and associated disorders |
摘要 |
Compositions and methods for identifying and/or modulating RNA transcripts and/or genes involved in fragile X syndrome and other associated disorders are provided. In particular, RNA targets for fragile X mental retardation protein (FMRP) have been identified by a novel monoclonal antibody to FMRP and a consensus sequence for the RNA binding region has been identified. Arrays for identifying compounds, proteins, nucleotides, and the like that modulate the RNA targets or associated genes are provided. Additionally, methods for modulating RNA targets are provided. |
申请公布号 |
AU2002363656(A1) |
申请公布日期 |
2003.05.26 |
申请号 |
AU20020363656 |
申请日期 |
2002.11.15 |
申请人 |
EMORY UNIVERSITY;DUKE UNIVERSITY;THE ROCKEFELLER UNIVERSITY |
发明人 |
STEPHANIE CEMAN;JACK D. KEENE;ROBERT B. DARNELL;STEPHEN T. WARREN;VICTORIA BROWN-KENNERLY;PENG JIN;SCOTT A. TENENBAUM;JENNIFER C. DARNELL |
分类号 |
A01K67/027;C07H21/04;C07K14/705;C07K16/28;C12Q1/68;(IPC1-7):C12Q1/68;A61K48/00;C12P19/34 |
主分类号 |
A01K67/027 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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