| 摘要 |
1358008 Cephalosporins TAKEDA YAKUHIN KOGYO KK 7 July 1972 [12 July 1971 9 March 1972] 32000/72 Addition to 1304647 Heading C2A Novel cephalosporin derivatives of general Formula I wherein R is a halogen atom, a nitro, amino or carboxyl group or a substituted or unsubstituted lower alkyl group, n is 0 or an integer of 1 to 3 and X is a hydrogen or halogen atom, each of the groups R being the same or different when n is greater than 1, or a salt thereof, are prepared (a) by reacting a compound of general Formula II R and n being as previously defined, or a salt thereof, with a compound of general Formula III X being as previously defined, or a salt thereof; or (b) reacting a compound of general Formula IV X being as previously defined, or a salt or ester thereof, with a compound of general Formula V R and n being as previously defined, or a functional derivative thereof. Pharmaceutical compositions having broad spectrum antibiotic activity comprise a cephalosporin derivative of Formula (I) as defined above or a salt thereof and a pharmaceutically acceptable carrier or diluent. The compositions may be administered orally or parenterally. |
