| 摘要 |
AN INSULIN ANALOGUE COMPRISES A B-CHAIN POLYPEPTIDE INCORPORATING A HALOGENATED PHENYLALANINE AT POSITION B24, B25 OR 826.THE HALOGENATED PHENYLALANINE MAY BE ORTHOMONOFLUORO-PHENYLALANINE, ORTHO-MONOBROMO-PHENYLALANINE OR ORTHO-MONOCHLORO-PHENYLALANINE.THE ANALOGUE MAY BE OF A MAMMALIAN INSULIN, SUCH AS HUMAN INSULIN.A NUCLEIC ACID ENCODES SUCH AN INSULIN ANALOGUE.THE HALOGENATED INSULIN ANALOGUES RETAIN SIGNIFICANT ACTIVITY.A METHOD OF TREATING A PATIENT COMPRISES ADMINISTERING A PHYSIOLOGICALLY EFFECTIVE AMOUNT OF THE INSULIN ANALOGUE OR A PHYSIOLOGICALLY ACCEPTABLE SALT THEREOF TO A PATIENT.HALOGEN SUBSTITUTION-BASED STABILIZATION OF INSULIN MAY ENHANCE THE TREATMENT OF DIABETES MELLITUS IN REGIONS OF THE DEVELOPING WORLD LACKING REFRIGERATION. |
