ACETOPHENONE DERIVATIVE AND ITS PREPARATION

摘要

NEW MATERIAL:3-Benzoylacetophenone of formulaI. USE:Useful as an intermediate for preparing 2-(3-benzoylphenyl)-propionic acid useful acid useful as a medicine. PROCESS:A compound of formula II (R<3> and R<4> are alkyl groups or together from a cyclic alkyl group) is reacted with benzaldehyde to give a secondary alcohol of formula III, which is then deacetalized with an acid, e.g. sulfuric acid or p-toluenesulfonic acid, in water or acetone solvent at 10-30 deg.C to afford the compound of formulaI. The starting compound of formula II is obtained by reacting m-bromoacetophenone of formula IV with an alcohol in the presence of an acidic catalyst under the azeotropic conditions, and reacting the resultant acetal of formula V with metallic magnesium in an ethereal solvent.