VINYLTHIOACETAMIDO OXACEPHALOSPORIN DERIVATIVES, AND INTERMEDIATES THEREFOR, THEIR PREPARATION, FORMULATIONS CONTAINING THE SAME AND THEIR ANTIBACTERIAL USE

摘要

A compound of the formula: (I) wherein u represents hydrogen, carboxamido, N-hydroxycarboxamido, carboxy, azido, an aryl, an acylamino, a protected carboxy or an N-alkoxycarboxamido, or, together with v, can represent -S- or -CH2S-; v represents hydrogen, halogen, cyano or an alkylthio, or, together with u, can represent -S- or -CH2S-, or, together with w, can represent -(CH2)3CO-; w represents hydrogen, carboamoyl, cyano, carboxy, an N-alkylcarbamoyl, an alkyl, an aryl, a protected carboxy or a heterocycle, or, together with v, can represents -(CH2)3CO-; x represents halogen, trifluoromethyl, an alkylthio or an arylthio; y represents hydrogen, a light metal or a carboxylic acid protecting group; and z represents an acyloxy or a heterocycle-thio, each of the above radicals represented by the symbols u, v, w, x, y and z being optionally substituted by halogen or a carbon-, nitrogen-, oxygen- or sulfur-containing functional group, a process for preparing the compound, a pharmaceutical composition containing the compound, and a therapeutical use of the compound. A compound of the formula: (III) wherein u, v, w and x are as defined above, useful as a starting compound for preparing the compound (I) is also provided.