Method of inhibiting the transcription of genes

摘要

PCT No. PCT/EP94/01014 Sec. 371 Date Jan. 22, 1996 Sec. 102(e) Date Jan. 22, 1996 PCT Filed Mar. 31, 1994 PCT Pub. No. WO94/23045 PCT Pub. Date Oct. 13, 1994Inhibition of the transcription of genes in higher eukaryotic cells by inhibiting the activation of NF-KB, wherein the cells are treated with substances which specifically inhibit the proteolytic degradation of IKB- alpha directly or indirectly. Process for screening substances which inhibit NF-KB activation by inhibiting the proteolytic degradation of IKB- alpha . Use of the substances for treating pathological conditions which can be traced back to undesirable gene expression controlled by NF-KB.