发明名称 |
Heteroarylnaphthalene lactones as inhibitors of leukotriene biosynthesis |
摘要 |
Compounds having the formula I: <IMAGE> I are inhibitors of leukotriene biosynthesis. These compounds are useful as anti-asthmatic, anti-allergic, anti-inflammatory, and cytoprotective agents. They are also useful in treating angina, cerebral spasm, glomerular nephritis, hepatitis, endotoxemia, uveitis, and allograft rejection and in preventing the formation of atherosclerotic plaques.
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申请公布号 |
US5428060(A) |
申请公布日期 |
1995.06.27 |
申请号 |
US19920936809 |
申请日期 |
1992.08.27 |
申请人 |
MERCK FROSST CANADA, INC. |
发明人 |
DUCHARME, YVES;GILLARD, JOHN W.;FORTIN, REJEAN;DUBE, DANIEL;GIRARD, YVES;HAMEL, PIERRE;DELORME, DANIEL |
分类号 |
C07D405/14;C07D407/14;C07D409/14;C07D493/08;(IPC1-7):A61K31/36;A61K31/365 |
主分类号 |
C07D405/14 |
代理机构 |
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代理人 |
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地址 |
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