DERIVATIVES OF SUCCINAMIDE AND THEIR USE AS METALLOPROTEINASE INHIBITORS

摘要

Compounds of formula (I), wherein X is a -CO2H or -CONHOH group; R4 is a group -CHR<x>R<y> wherein R<x> and R<y> independently represent optionally substituted phenyl or monocyclic heteroaryl rings, which optionally may be linked covalently to each other by a bond or by a C1-C4 alkylene or C2-C4 alkenylene bridge; and R1, R2, R3 and R5 as defined in the specification are selective inhibitors of stromelysin-1 and matrilysin relative to human fibroblast collagenase and 72KDa gelatinase.