Methods and system for breathing-synchronized, target-tracking radiation therapy

摘要

Preparing a plan to synchronize radiation delivery to a target in a patient with patient breathing phase and amplitude as the independent variable comprising (a) obtaining simultaneous data on patient breathing and target shape and location, (b) correlating the data and optimizing the correlation, (c) establishing optimal parameters of radiation delivery for each breathing phase/amplitude or for each target shape/location; and (d) synchronizing radiation delivery to a target in a patient with patient breathing comprising (a) positioning the patient, (b) monitoring actual breathing or the shape/location of the target, and (c) while monitoring, delivering radiation to the target according to a plan; and a system for controlling radiation delivery by a device to a target in a patient comprising (i) a processor, which receives and processes data on breathing or the shape/location of the target, and (ii) a controller, which controls radiation delivery to the target according to a plan, which synchronizes radiation delivery to the target with breathing data or the shape/location of the target.

主权项

1. A method of preparing a plan to synchronize delivery of radiation to a target in a patient, wherein the method comprises:
(a) obtaining simultaneous imaging data on the patient's breathing and tracking of the target in the patient, wherein the data on the breathing of the patient includes the phase and amplitude of breaths and the data on the tracking of the target includes a location of the target and a shape of the target, (b) correlating the data on the breathing of the patient and the data on the tracking of the target in the patient and optimizing the correlation, whereupon a three-dimensional image of the patient for each phase/amplitude of breath is generated, and (c) establishing optimal parameters for the delivery of radiation by a machine to the target in the patient for each phase/amplitude of breath in view of the optimized correlation of (b), whereupon a look-up table for the plan of synchronizing delivery of radiation to the target in the patient is prepared.