| 发明名称 |
Caspase inhibitors and the use thereof |
| 摘要 |
The present invention is directed to novel dipeptide thereof, represented by the general Formula I:where R1-R3, X and Y are defined herein. The present invention also relates to the discovery that compounds having Formula I are potent inhibitors of caspases and apoptotic cell death. Therefore, the inhibitors of this invention can retard or block cell death in a variety of clinical conditions in which the loss of cells, tissues or entire organs occurs.
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| 申请公布号 |
US6355618(B1) |
申请公布日期 |
2002.03.12 |
| 申请号 |
US20000545565 |
申请日期 |
2000.04.07 |
| 申请人 |
CYTOVIA, INC. |
发明人 |
CAI SUI XIONG;WEBER ECKARD;WANG YAN;MILLS GORDON B.;GREEN DOUGLAS R. |
| 分类号 |
C12N9/99;A61K38/00;A61P1/02;A61P1/04;A61P1/08;A61P1/16;A61P1/18;A61P3/10;A61P7/00;A61P7/06;A61P7/08;A61P9/04;A61P9/10;A61P13/10;A61P13/12;A61P15/08;A61P17/02;A61P17/06;A61P17/14;A61P25/00;A61P25/02;A61P25/14;A61P25/16;A61P25/28;A61P25/32;A61P27/02;A61P27/06;A61P29/00;A61P31/04;A61P31/12;A61P31/18;A61P35/00;A61P37/00;A61P37/02;A61P39/02;A61P43/00;C07C237/22;C07C271/22;C07C311/19;C07D295/205;C07D311/16;C07D311/66;C07K5/06;C12N1/16;(IPC1-7):A61K38/05;C07D213/04;C07D311/06 |
主分类号 |
C12N9/99 |
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