Oral pharmaceutical compositions of fenofibrate having high bioavailability

摘要

The present invention relates to oral pharmaceutical compositions of fenofibrate having high bioavailability with improved dissolution and methods for providing the pharmaceutical compositions. The oral pharmaceutical composition of fenofibrate include an inert hydro-insoluble carrier having one or more one layers that include fenofibrate in a micronized form, one or more hydrophilic polymers, and one or more surfactants. The composition may have a dissolution profile of at least about 10% in about 5 minutes, about 20% in about 10 minutes, about 50% in about 20 minutes and about 75% in about 30 minutes, as measured using the rotating blade method at 75 rpm according to the European Pharmacopoeia in a dissolution medium constituted by water with 2% by weight of Polysorbate 80 or with 0.025M sodium lauryl sulphate.