发明名称 |
Gram-positive bacteria specific binding compounds |
摘要 |
The present invention provides improved binding compounds capable of specifically binding Gram-positive bacteria. Binding compounds are provided that are fully human, enabling therapeutic applications in human individuals. |
申请公布号 |
US9458228(B2) |
申请公布日期 |
2016.10.04 |
申请号 |
US201514728826 |
申请日期 |
2015.06.02 |
申请人 |
Genentech, Inc.;AIMM Therapeutics B.V. |
发明人 |
Beaumont Tim;Kwakkenbos Mark Jeroen;Brown Eric J.;Morisaki John Hiroshi;Hazenbos Wouter L. W.;Mariathasan Sanjeev;Kajihara Kimberly;Xia Yi |
分类号 |
C07K16/12 |
主分类号 |
C07K16/12 |
代理机构 |
Morrison & Foerster LLP |
代理人 |
Morrison & Foerster LLP |
主权项 |
1. A method for producing an antibody or functional part thereof comprising providing an isolated cell with a nucleic acid encoding said antibody or functional part thereof, wherein said antibody or functional part thereof comprises a heavy chain variable domain and a light chain variable domain comprising:
(a) a heavy chain CDR1 sequence RFAMS (SEQ ID NO:1), and (b) a heavy chain CDR2 sequence SINNGNNPYYARSVQY (SEQ ID NO:2), and (c) a heavy chain CDR3 sequence DHPSSGWPTFDS (SEQ ID NO:3), and (d) a light chain CDR1 sequence RASENVGDWLA (SEQ ID NO:4), and (e) a light chain CDR2 sequence KTSILES (SEQ ID NO:5), and (f) a light chain CDR3 sequence QHYXRFPYT (SEQ ID NO:6), wherein X is I or M,allowing said cell to translate said nucleic acid thereby producing said antibody or functional part thereof, and further harvesting, purifying and/or isolating the antibody or functional part thereof. |
地址 |
South San Francisco CA US |