发明名称 Gram-positive bacteria specific binding compounds
摘要 The present invention provides improved binding compounds capable of specifically binding Gram-positive bacteria. Binding compounds are provided that are fully human, enabling therapeutic applications in human individuals.
申请公布号 US9458228(B2) 申请公布日期 2016.10.04
申请号 US201514728826 申请日期 2015.06.02
申请人 Genentech, Inc.;AIMM Therapeutics B.V. 发明人 Beaumont Tim;Kwakkenbos Mark Jeroen;Brown Eric J.;Morisaki John Hiroshi;Hazenbos Wouter L. W.;Mariathasan Sanjeev;Kajihara Kimberly;Xia Yi
分类号 C07K16/12 主分类号 C07K16/12
代理机构 Morrison & Foerster LLP 代理人 Morrison & Foerster LLP
主权项 1. A method for producing an antibody or functional part thereof comprising providing an isolated cell with a nucleic acid encoding said antibody or functional part thereof, wherein said antibody or functional part thereof comprises a heavy chain variable domain and a light chain variable domain comprising: (a) a heavy chain CDR1 sequence RFAMS (SEQ ID NO:1), and (b) a heavy chain CDR2 sequence SINNGNNPYYARSVQY (SEQ ID NO:2), and (c) a heavy chain CDR3 sequence DHPSSGWPTFDS (SEQ ID NO:3), and (d) a light chain CDR1 sequence RASENVGDWLA (SEQ ID NO:4), and (e) a light chain CDR2 sequence KTSILES (SEQ ID NO:5), and (f) a light chain CDR3 sequence QHYXRFPYT (SEQ ID NO:6), wherein X is I or M,allowing said cell to translate said nucleic acid thereby producing said antibody or functional part thereof, and further harvesting, purifying and/or isolating the antibody or functional part thereof.
地址 South San Francisco CA US