| 发明名称 |
Methods and compositions using Klotho-FGF fusion polypeptides |
| 摘要 |
The present invention is directed to fusion polypeptides comprising a Klotho protein or an active fragment thereof and FGF23 or an active fragment thereof. |
| 申请公布号 |
US9458209(B2) |
申请公布日期 |
2016.10.04 |
| 申请号 |
US201313904574 |
申请日期 |
2013.05.29 |
| 申请人 |
NOVARTIS AG |
发明人 |
Glass David;Hu Shou-Ih |
| 分类号 |
A61K38/18;A61K39/395;C07K14/50;C07K16/00;C12N1/21;C12N5/10;C07K14/435;C12N9/24;A61K38/00 |
主分类号 |
A61K38/18 |
| 代理机构 |
|
代理人 |
Le Hong-Van M. |
| 主权项 |
1. A fusion polypeptide comprising, in order from N-terminus to C-terminus, a polypeptide comprising the sequence of amino acids 34 to 982 of SEQ ID NO: 19; one or more linkers; and a polypeptide comprising the sequence of amino acids 1000 to 1228 of SEQ ID NO: 19,
wherein the fusion polypeptide is capable of activating Egr-1. |
| 地址 |
Basel CH |
