| 摘要 |
There is described a process for the production of theophylline derivatives of the formula <IMAGE> I where T is the theophyllinyl-(7)-residue, Alk is a straight or branched alkylene chain having 2 to 4 carbon atoms, R is hydrogen or a methyl group, n is 1 or 2 with the proviso that two hydroxy groups of the phenyl ring cannot be in the 3,4-positions by reacting an aminoalkyltheophylline of the formula <IMAGE> II with a bromoketone of the formula <IMAGE> III where R' is a lower alkyl group and the two -OCOR' groups of the phenyl ring cannot be in the 3,4 positions to an intermediate compound of the formula <IMAGE> IV and subsequently hydrolytically splitting off the R'CO protective group wherein the bromoketone of formula III is produced free of dibromide by bromination of a ketone of the formula <IMAGE> V followed by treatment with a lower trialkyl phosphite. |
