| 摘要 |
<p>NEW MATERIAL:The titled compound expressed by formula I (x and y are integers 1-5; z is 0 or 1; R1 and R2 are Hs, lower alkyls, etc., however not H at the same time). EXAMPLE:7beta- ( 2D-2-Amino-2-methoxycarbonylethylthioacetamido ) -7alpha- methoxy- 3-(1-methyl-1H-tetrazole-5-yl)thiomethyl-3-cephem-4-carboxylic acid. USE:A medicine having an in vivo antimicrobial activity, particularly a powerful antimicrobial action on a wide range of microorganisms, particularly Gram-positive and Gram-negative bacteria and a good oral administering effect. PROCESS:A compound of formula II (Z is H or releasable amino-protecting group) is reacted with a compound of formula III (R3 is lower alkyl, lower acyl, etc.; X is halogen; Y is H or lower alkyl) in an inert solvent in the presence of a base, e.g. a trialkylamine, as an acid binder to give the compound of formula I.</p> |
