| 摘要 |
NEW MATERIAL:The pyridone derivative of formula I (X1 and X2 are halogen; Y is N, CH or CF; R1 is lower alkyl, lower alkenyl or cycloalkyl; R2 and R3 are H, lower alkyl or cycloalkyl; k is 3, 4 or 5; m and n are 0, 1 or 2), its ester and its salt. EXAMPLE:7-(3-Amino-4-fluoro-1-pyrrolidinyl)-1-cyclopropyl-6-fluoro-1,4 -dihydro-4- oxo-1,8-naphthyridine-3-carboxylic acid hydrochloride. USE:An antibacterial agent useful for the preservative for pharmaceuticals, agricultural chemicals and foods, or its intermediate. PREPARATION:The compound of formula I can be produced by reacting the carboxylic acid of formula II (Z is reactive functional group such as halogen, arylsulfonyl, etc.) or its ester (preferably lower alkyl ester) with the cyclic amine derivative of formula III. |
