| 摘要 |
A novel receptor protein tyrosine kinase named ork (orphan receptor tyrosine kinase) is identified and characterized. cDNA encoding the ork protein is inserted into an expression vector for production of the protein via recombinant DNA technology. The ork cDNA, when transfected into Cos-7 cells, encodes a 140 Kd protein with in vitro kinase activity. The ork gene is expressed predominantly in placenta and lung, with lower levels in umbilical vein endothelial cells, brain and kidney. |
