Sorbent comprising on its surface a cationic or protonizable aliphatic residue for the purification of organic molecules

摘要

The present invention relates to a sorbent comprising a solid support material, the surface of which comprises a residue of a general formula (I), wherein the residue is attached via a covalent single bond to a functional group on the surface of either the bulk solid support material itself or of a polymer film on the surface of the solid support material. Furthermore, the present invention relates to the use of the sorbent according to the invention for the purification of organic molecules, in particular pharmaceutically active compounds, preferably in chromatographic application.

主权项

1. A sorbent comprising a solid support material, wherein the surface of the solid support material comprises a residue of the following general formula (I): wherein the residue is attached via a covalent single bond represented by the dotted line in formula (I) to a functional group on the surface of either the bulk solid support material itself or a polymer film on the surface of the solid support material, and wherein:
(a) L represents a covalent single bond or is an (h+1)-valent linear aliphatic hydrocarbon group comprising 1 to 30 carbon atoms, or an (h+1)-valent branched or cyclic aliphatic hydrocarbon group comprising 3 to 30 carbon atoms, wherein:
(i) one or more CH2-moieties in said groups may be substituted by a —C(O)—, —C(O)NH—, O, S, or —S(O)2—; and(ii) one or more hydrogen atoms may be substituted by D, F, Cl, or OH;(b) PB represents n organic cationic group or an organic protonizable group;(c) h is an index representing the number of PB-moieties bound to L and is 1, 2 or 3; andwith the proviso that, if L represents a covalent single bond, h is 1 and PB binds to the functional group via a carbon atom of the group PB.