发明名称 |
AMIDOPYRIDINOL DERIVATIVE OR PHARMACEUTICALLY ACCEPTABLE SALT THEREOF AND PHARMACEUTICAL COMPOSITION COMPRISING SAME AS ACTIVE COMPONENT |
摘要 |
The present invention relates to an amidopyridinol derivative or a pharmaceutically acceptable salt thereof, and a pharmaceutical composition including an amidopyridinol derivative or a pharmaceutically acceptable salt thereof as an active component. An amidopyridinol derivative represented by Chemical Formula 1 or a pharmaceutically acceptable salt thereof has an excellent antiangiogenic effect in a chorioallantoic membrane model, and thus is useful as an agent for preventing or treating diseases associated with angiogenesis, such as macular degeneration or arthritis, and also has an excellent colitis-inhibitory effect in a model of inflammatory bowel diseases, and thus is useful as an agent for preventing or treating inflammatory bowel diseases. Upon inoculation of lung cancer cells in a chorioallantoic membrane model, the amidopyridinol derivative of Chemical Formula 1 or the pharmaceutically acceptable salt thereof inhibits angiogenesis and tumor growth that are caused by tumorigenesis, and also inhibits the activity of cathepsin S that plays an important role in metastasis and invasion of cancer, and thus is useful as an inhibitor of cancer growth and metastasis. |
申请公布号 |
EP2987786(A4) |
申请公布日期 |
2016.12.28 |
申请号 |
EP20140785427 |
申请日期 |
2014.04.21 |
申请人 |
Industry Academic Cooperation Foundation of Yeungnam University |
发明人 |
JEONG, Byeong Seon;KIM, Jung Ae;NAM, Tae gyu;LEE, Hyun Ji;KIM, Dong Guk;KANG, You Ra;BEEN, Jae Hui;JIN, You Jin;REGMI, Sushil Chandra;GAUTAM, Jaya |
分类号 |
C07D213/75;A61K31/44;A61K31/443;A61K31/4436;A61P19/02;A61P29/00;A61P35/00;C07D405/12;C07D409/12 |
主分类号 |
C07D213/75 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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