| 摘要 |
The present invention relates to screening methods for diabetes drugs. In particular, the invention concerns a method for identifying a drug against diabetes comprising determining the amount of glyoxylate in a test sample of a subject suffering from diabetes or a diabetes-like condition, wherein said test sample has been taken after the subject has been brought into contact with a compound suspected to be a drug against diabetes and comparing the determined amount to a reference amount for glyoxylate, whereby a compound being a drug against diabetes is identified. Further contemplated is a method for identifying a drug against diabetes comprising contacting test cells which produce glyoxylate with a compound suspected to be a drug against diabetes for a time and under conditions which allow for said compound to interact with the cells and to affect glyoxylate production, determining the amount of glyoxylate produced in said cells, and comparing the determined amount to a reference amount for glyoxylate, whereby a compound being a drug against diabetes is identified. Finally, a method for the manufacture of a drug against diabetes is provided. |
