发明名称 |
BIOTECHNOLOGICAL SULPHATED CHONDROITIN SULPHATE AT POSITION 4 OR 6 ON THE SAME POLYSACCHARIDE CHAIN, AND PROCESS FOR THE PREPARATION THEREOF |
摘要 |
The present invention discloses a process for the production of chondroitin sulphate with an average molecular weight (Mw) of 10-30 kDa by chemical sulphation starting from an unsulphated chondroitin backbone, obtained in turn by acid hydrolysis of capsular polysaccharide K4 made directly from E. coli strain O5:K4:H4, or directly produced from a genetically modified strain of E. coli. Sulphation of the N-acetyl-D-galactosamine residue at position 4 or 6 takes place simultaneously in the same polysaccharide chain, simulating the sulphation pattern observed in natural chondroitin sulphate, unlike the sulphation obtained with the synthesis methods described to date. |
申请公布号 |
EA023849(B1) |
申请公布日期 |
2016.07.29 |
申请号 |
EA20130091673 |
申请日期 |
2012.05.10 |
申请人 |
GNOSIS S.P.A. |
发明人 |
BIANCHI DAVIDE;VALETTI MARCO;BAZZA PAOLA;MIRAGLIA NICCOLO;VALOTI ERMANNO |
分类号 |
C08B37/08;A61K31/737;C08L5/08 |
主分类号 |
C08B37/08 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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