Use of CB1 antagonists and/or inverse agonists for the preparation of drugs that increase motor neuron excitability

摘要

Use of a CB1 receptor antagonist and/or inverse agonist, preferably rimonabant, for the preparation of drugs useful for increasing motor neuron excitability in the cerebral cortex and/or in the brain stem and/or at the spinal level, as well as a method for increasing motor neuron excitability through the administration of a CB1 antagonist/ inverse agonist receptors, and to the use of a pharmaceutical composition which comprises a CB1 receptor antagonist and/or inverse agonist, preferably rimonabant, for increasing motor neuron excitability in the cerebral cortex and/or in the brain stem and/or at the spinal level.

主权项

1. A method for the treatment of fatigue associated with spinal cord lesions or with Parkinson's disease, comprising administering to a patient in need thereof an effective amount of a CB1 receptor antagonist, characterized in that the CB1 receptor antagonist and/or inverse agonist is selected from the group consisting of rimonabant, a compound of the following formula: and any of their pharmaceutically acceptable salts and/or inverse agonist.