BACTERIA ENGINEERED TO TREAT DISEASES THAT BENEFIT FROM REDUCED GUT INFLAMMATION AND/OR TIGHTENED GUT MUCOSAL BARRIER

摘要

Genetically engineered bacteria, pharmaceutical compositions thereof, and methods of treating or preventing autoimmune disorders, inhibiting inflammatory mechanisms in the gut, and/or tightening gut mucosal barrier function are disclosed.

主权项

1. A bacterium comprising a non-native gene cassette for producing butyrate, wherein the gene cassette is operably linked to a directly or indirectly inducible promoter that is induced by exogenous environmental conditions found in a mammalian gut.