发明名称 CRYSTALLINE FORMS OF (R)-N-((4-METHOXY-6-METHYL-2-OXO-1,2-DIHYDROPYRIDIN-3-YL)METHYL)-2-METHYL-1-(1-(1-(2,2,2-TRIFLUOROETHYL)PIPERIDIN-4-YL)ETHYL)-1H-INDOLE-3-CARBOXAMIDE
摘要 The present disclosure relates to a crystalline Forms A, B, and C of (R)-N-((4-methoxy-6-methyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-2-methyl-1-(1-(1-(2,2,2-trifluoroethyl)piperidin-4-yl)ethyl)-1H-indole-3-carboxamide, each of which are useful as modulators the activity of histone methyl modifying enzymes. The present disclosure also provides pharmaceutically acceptable compositions comprising the crystalline forms and methods of using said compositions in the treatment of various disorders. Formula (I)
申请公布号 WO2017040190(A1) 申请公布日期 2017.03.09
申请号 WO2016US48616 申请日期 2016.08.25
申请人 CONSTELLATION PHARMACEUTICALS, INC.;CORSON, Donald 发明人 CORSON, Donald;ALBRECHT, Brian, K.;ARRIGO, Alisha;GEHLING, Victor, S.;HACHÉ, Bruno, Patrice;HARMANGE, Jean-Christophe;LANE, Jonathan
分类号 C07D401/14;A61K31/4545;A61P35/00 主分类号 C07D401/14
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