发明名称 |
CRYSTALLINE FORMS OF (R)-N-((4-METHOXY-6-METHYL-2-OXO-1,2-DIHYDROPYRIDIN-3-YL)METHYL)-2-METHYL-1-(1-(1-(2,2,2-TRIFLUOROETHYL)PIPERIDIN-4-YL)ETHYL)-1H-INDOLE-3-CARBOXAMIDE |
摘要 |
The present disclosure relates to a crystalline Forms A, B, and C of (R)-N-((4-methoxy-6-methyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-2-methyl-1-(1-(1-(2,2,2-trifluoroethyl)piperidin-4-yl)ethyl)-1H-indole-3-carboxamide, each of which are useful as modulators the activity of histone methyl modifying enzymes. The present disclosure also provides pharmaceutically acceptable compositions comprising the crystalline forms and methods of using said compositions in the treatment of various disorders. Formula (I) |
申请公布号 |
WO2017040190(A1) |
申请公布日期 |
2017.03.09 |
申请号 |
WO2016US48616 |
申请日期 |
2016.08.25 |
申请人 |
CONSTELLATION PHARMACEUTICALS, INC.;CORSON, Donald |
发明人 |
CORSON, Donald;ALBRECHT, Brian, K.;ARRIGO, Alisha;GEHLING, Victor, S.;HACHÉ, Bruno, Patrice;HARMANGE, Jean-Christophe;LANE, Jonathan |
分类号 |
C07D401/14;A61K31/4545;A61P35/00 |
主分类号 |
C07D401/14 |
代理机构 |
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主权项 |
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