The present invention relates to methods and pharmaceutical compositions for reducing arterial stiffness in a human patient showing at least one symptom selected from increased pulse wave velocity (PWV) and increased pulse pressure (PP) comprising administration to said patient of a therapeutically effective amount or a prophylactically effective amount of a combination of a therapeutic agent blocking the angiotensin receptor and a therapeutic agent inhibiting the NEP enzyme, in particular of a combination of sacubitril or a pharmaceutically acceptable salt thereof and valsartan or a pharmaceutically acceptable salt thereof in a 1:1 molar ratio.
申请公布号
WO2017037577(A1)
申请公布日期
2017.03.09
申请号
WO2016IB55045
申请日期
2016.08.24
申请人
NOVARTIS AG;GODTFREDSEN, Sven Erik;ZAPPE, Dion Hubert;GUO, Weinong;ZHANG, Jack Ziyu
发明人
GODTFREDSEN, Sven Erik;ZAPPE, Dion Hubert;GUO, Weinong;ZHANG, Jack Ziyu