发明名称 |
RADIOLABELING OF ADENO ASSOCIATED VIRUS |
摘要 |
Provided herein are systems and methods for radiolabeling of recombinant Adeno-Associated Virus (rAAV) with radioactive iodine. Also provided are methods for in vivo imaging and treatment using the radiolabeled rAAV. |
申请公布号 |
US2017067028(A1) |
申请公布日期 |
2017.03.09 |
申请号 |
US201615154647 |
申请日期 |
2016.05.13 |
申请人 |
Ballon Douglas J.;Crystal Ronald G.;Kaminsky Stephen;Kothari Paresh;De Bishnu;Sondhi Dolan;Vallabhajosula Shankar;Babich John |
发明人 |
Ballon Douglas J.;Crystal Ronald G.;Kaminsky Stephen;Kothari Paresh;De Bishnu;Sondhi Dolan;Vallabhajosula Shankar;Babich John |
分类号 |
C12N7/00;A61K51/12;G01N33/60 |
主分类号 |
C12N7/00 |
代理机构 |
|
代理人 |
|
主权项 |
1. A method for producing a recombinant adeno-associated virus (rAAV) labeled with radioactive iodine comprising contacting a composition containing rAAV particles with activated radiolabeled iodine to form a mixture and incubating the mixture at about 4-5° C. for at least 10 minutes. |
地址 |
Gillette NJ US |